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TOP > Clients and Collaborative Researches

client and Collaborative researchhome

Natural Resource Library

Our natural products libraries are made from recent collections of untouched marine bioresources. Duplication of compounds in our libraries is minimized by using our own diversity analysis system so samples can be screened efficiently. The likelihood of novel compound discovery is therefore high.

 Natural resource 1

Drug Discovery 

OPBIO has the expertise and resources to support natural product drug discovery and development research. A few examples of our natural product contract and collaborative researches on drug discovery are listed below:

  •  ·     OPBIO’s phenotypic screening resulted in finding an antifungal agent, Kakeromycin (PCT submitted),
           bearing a novel scaffold. The microbial strain (A84) was isolated from a seabed mud samples from
           Kakeromajima around Amami Island. A84 produced kakeromycin only if the medium contains seawater.
Drug Discovery 1

 

·    Ten more hit strains with antifungal activity were identified using the OPBIO phenotypic
screening. We currently use this method in searching for antibacterial and antifungal compounds but we will expand to cover anticancer and antiviral compounds.

·      Screening of our microalgal library resulted in discovering a new antifungal compound.

·      We set up panel of biological assays to screen our library, follow up hits by fractionation and dereplication, then isolation and structural elucidation of potential leads.

·       In a joint research with Kitasato University, Terretonin G, a new sesterterpenoid antibiotic from   marine-derived Aspergillus sp. OPMF00272 was isolated. JAntib, 67, 593-595, (2014).

·      Collaborative project with Nagoya University resulted in the isolation of novel diyne tetraols,
Petrosiols A–E, from an Okinawan marine sponge
Petrosia strongylata. The compounds induce nerve growth factor (NGF)-like neuronal differentiation of PC12 cells. Tetrahedron, 69 101-106, (2013).

·       Isolation and structure elucidation of JBIR-44, a new bromotyrosine cytotoxic compound from a marine sponge Psammaplysilla purpurea, a joint research with Tokyo Univ. of Marine Sci. & Tech. and National Institute of Advanced Industrial Science and Technology (AIST, Japan). JAntib, 62, 393-395, (2009).

Cosmetics

Using OPBIO’s natural products library and the available information on our biological resources, we have contracted and collaborative researches for cosmetic applications with the following results:

·    We have discovered microalgal strains that contain fatty acids important to the cosmetic industry.

·    Information from our database on Okinawan medicinal and edible plants has led to two patent applications of our clients and collaborators in cosmetic industries

·    A joint research with Okinawa National College of Technology resulted in the discovery of a lactic acid bacterium with tyrosinase inhibitory activity.

Food

Natural products are very important sources of food products for proper nutrition. OPBIO has supported food companies with the following:

·     Availability of information on traditional uses(medicinal,food) of bioresources endemic in Okinawa. This has garnered much interest since the Okinawan people is known for their longevity due to diet.

·     Isolation of lactic acid and bacteria from local fermented food for different applications

·     Screening of our microalgal library for omega-3-fatty acids resulted in discovering high EPA- and DHA-producing strains

·     Fractionation of edible plant extracts to isolate food seasoning

·     Screening edible microbes for enzymes that can be used to improve certain food and food products

健康食品、調味料などの探索研究

Industrial Chemicals and Biocatalysts

OPBIO can collect the macroorganisms or microbial resources containing a target compound or enzymatic activity.

We have projects that involves:

·     Recollection of macro organism such as micro algae and isolation of a target compound in gram quantities

·     Optimization of fermentation and isolation methods to produce gram quantities of target compound from microbial resources.

·     Setting up assay systems to evaluate specific enzyme production, then screening our strains for activities

·     Collection of microbial resources for enzymes that can catalyze oil degradation and DXNs decomposition

Enzyme purification and further product improvement

Industirla Chemicals & Biocatalysts

Energy

Many microalgal strains producing hydrocarbons are present in the OPBIO collection. We have developed method for separating cultures and selectively collecting the hydrocarbon-producing strains of interest.
We can implement productivity optimization by studying media and culture conditions. In addition, we collaborate with Okinawa Institute of Science and Technology (OIST) Graduate School and Okinawa Prefecture PJ on productivity improvement research including genome analysis and genetic manipulation.
 

Energy