Terretonin G, a new sesterterpenoid antibiotic from marine-derived Aspergillus sp. OPMF00272

Marine-derived microorganisms are known as producers of many structurally unique and strong-bioactive compounds, including clinical medicines and research reagents.1, 2, 3, 4 During our screening for new metabolites from marine-derived fungi, one new sesterterpenoid, named terretonin G (1), was isolated from the culture broth of Aspergillus sp. OPMF00272 along with eight known natural products, terretonin (2),5, 6, 7 LL-S490β (3),⁸ methyl-3,4,5-trimethoxyl-2-[2-(nicotinamide)benzamido]benzoate (4),⁹ territrem B(5),¹⁰ aspernolid A (6),¹¹ butyrolactones I (7)¹² and V (8),¹³ and aspulvinone J (9)¹⁴ (Figure 1).